A rat retinal damage model predicts for potential clinical visual disturbances induced by Hsp90 inhibitors
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منابع مشابه
A rat retinal damage model predicts for potential clinical visual disturbances induced by Hsp90 inhibitors.
In human trials certain heat shock protein 90 (Hsp90) inhibitors, including 17-DMAG and NVP-AUY922, have caused visual disorders indicative of retinal dysfunction; others such as 17-AAG and ganetespib have not. To understand these safety profile differences we evaluated histopathological changes and exposure profiles of four Hsp90 inhibitors, with or without clinical reports of adverse ocular e...
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ژورنال
عنوان ژورنال: Toxicology and Applied Pharmacology
سال: 2013
ISSN: 0041-008X
DOI: 10.1016/j.taap.2013.09.018